For those taking Seroquel for psychosis or schizophrenia? What dose are you on, and how was it increased?
I’m 33 and have a long history of cocaine use, going back to my early teens. I recently experienced a severe psychotic episode, but looking back, the symptoms actually started months before things got that bad.
For months, I had been experiencing increasing paranoia. I believed cars were following me, that neighbors were shining some kind of X-ray-like light through the walls, and that there were cameras hidden in the smoke detector and blinds. My sleeping habits were also changing. I would stay awake at night, leave the house repeatedly, and spend long periods sitting in my car.
Eventually, I voluntarily admitted myself to a psychiatric hospital for three days. I explained some of the things I had been experiencing and was diagnosed with paranoid schizophrenia. They prescribed Seroquel 100 mg daily, without a titration schedule or follow-up appointment. I didn’t start taking it at that time.
After that hospitalization, my mental health deteriorated further. I began experiencing increasingly severe hallucinations, paranoia, and delusions. I was seeing things like police officers on rooftops and images in cars. At one point, I believed I was the president, that there was a bomb in my head, and that my family members were artificial intelligence.
During the worst part of the episode, I went approximately 48 hours without sleeping or eating and completely lost touch with reality. My behavior became dangerous, and my family struggled to get me help because I could still answer basic questions during evaluations.
After finally sleeping, I woke up substantially more like myself, before taking any Seroquel.
I then started taking the prescribed 100 mg consistently at bedtime for approximately 12 days. Initially, it made me very sleepy, but that effect gradually became less noticeable. I started taking it later because I wasn’t sleepy or ready for bed at my usual time.
Around October 12–14, my wife began noticing changes in my behavior again. She said I was becoming withdrawn, mentally distant, slow to respond, and sometimes seemed to stare into space. Occasionally, my answers didn’t quite make sense.
My family also noticed that I seemed lost and disconnected. I started spending long periods sitting alone in my car again, just like I had before my previous episode. I also went a couple of days without brushing my teeth, not eating and sleeping.
This started back while I was still taking Seroquel. More recently, I’ve missed may be two or more days of medication. My family is concerned because they recognize some of these behaviors from before my previous psychotic episode. I’ve been reluctant to return for another psychiatric evaluation because I’m worried about being hospitalized, and I don’t necessarily believe I need treatment right now. I also don’t want to put my family through that again. I was jumping out cars, I punched someone in the face, ended up with a swollen hand.
I’m trying to understand other people’s experiences because I’ve learned that 100 mg is relatively low compared with doses commonly used to treat schizophrenia and psychosis.
For those taking Seroquel for psychosis, schizophrenia, or similar symptoms:
What dose did you start on, and what dose are you currently taking?
Are you on immediate-release (IR) or extended-release (XR)?
Do you take your medication all at bedtime or divide it between morning and evening?
How quickly did your provider titrate your dose?
Did the sedating effects wear off after the first week or two?
Did you experience withdrawal, emotional flatness, brain fog, or feeling mentally disconnected?
If you missed two or three consecutive doses, did your prescriber restart you at your previous dose or begin titration again?
How long did it take before you noticed improvement in paranoia, hallucinations, or disorganized thinking?
Has anyone experienced symptoms returning even while taking their prescribed medication?
I used Ai to help me write this because I’m having trouble getting my thoughts out. I feel like I’m in a daze.