Has anyone else had several biologics lose effectiveness over time?

I was on Stelara for 6 years before it stopped working, even after doubling the dose in the last months before stopping. I then switched to Bimzelx, which I had to stop after a year due to bad side effects (infections etc.) and loss of effectiveness. Now, after about a year on Skyrizi, I'm experiencing constant painful flare-ups again.
Before biologics, I tried MTX and topicals (but those aren't viable options anymore for me)

I'm getting really stressed about what comes next, especially since I've already failed multiple biologics. I'm 21, and the thought of potentially going through this repeatedly for the rest of my life is pretty overwhelming.

Has anyone been in a similar situation? What are you on now, and did you eventually find something that worked long-term?

Hey how can I get my hair back thick can someone please help I went to a dermatologist an she told me I have scalp psoriasis so she prescribed me with ketoconazole shampoo 2% I don’t have flair up or itching an scabs anymore but my hair is still thin I need help

Have there been any cases of achieving remission when quitting alcohol?

Please do share any experience.

i’m just so over everything.

I think I have psoriasis, but I don’t want to try steroids because i’m severely afraid of TSW

I know we shouldn't remove the flakes for the Koebner phenomenon.

At the same time, the topical like ketoconazole and even clobetasol won't penetrate properly if you have a thick flake preventing it.

So what is the best way to remove the flakes? Can oils be used? Or anything?

Just coming to the end of my phototherapy course (NHS) and in my final skin assessment today, I was told that it basically hasn’t worked and that I’m going to have to speak to a consultant within the next few months about “other options”, and have been told to go back on enstilar (steroid cream) until then.

Just curious about those who have been in this situation, what came next for you? What did the consultant suggest next?

Anyone who have psoriasis i have been home for past 6 months up for a meet with same condition person basically i am from Thane Hit me up if you are available a meet

I was on skyrizi for a while but got off abiut a hesr ago when we started trying to concieve. My psoriasis is getting really bad but im really conserned about the lack of evidence skyrizi is safe while oregnant. I cant do most creams, ive hsd really weird reactions with a majority of them. I dont know what to do.