I don’t have time to wait for things to get better in maybe 10 years. I’m in my early 20s, a really pretty girl, and I have lots of goals in life. My brain is broken, my emotions are numb, and my libido is gone.
My cognitive issues terrify me because I’m forgetting more and more of my life day by day, and it’s been almost 3 years since I stopped taking my SSRI. I can’t remember anything, I have trouble recognizing people right away when I see them, and I have many other limitations. I miss feeling something again so much—no matter what it is.
I want to travel and see the world and just live my life.
I want to build a career and start a healthy family.
I'm so afraid I'll never be able to have children…

I want to take medication again that makes me feel a little more alive. Please, please, please—can someone tell me which antidepressant helped them feel better again??

Do you people have headache with pssd? Which part of head pain like crown pre fontal or whatm

​

As many of us with PSSD experience different physical symptoms, I've been dealing with extremely dry skin, and now I'm also experiencing significant hair loss.

I've tried minoxidil, but it doesn't seem to be helping.

My questions:

Has anyone with PSSD experienced extreme skin dryness along with hair loss?

Has anyone successfully stopped or reversed hair loss after PSSD?

If minoxidil doesn't work, what other treatments or investigations should I consider?

Could this be related to hormonal changes, nerve dysfunction, or something else?

I'd appreciate hearing from anyone who has experienced something similar and found a treatment that helped.

If someone has pssd,then will he get erection after viagra or not?

Recent bloodwork showed I was pretty deficient in vitamin B12. I started a sublingual B12 supplement that’s a high dose 2000mcg, which is what you’re supposed to do for deficiency to correct it. However, I’m aware that it acts pretty significantly on increasing neurotransmitters like serotonin and potentially exciting nerves. I’m already feeling some effects, for example, extremely vivid dreams and restless sleep when I was taking it at night for the first four days. Switched to the morning to help correct that issue but I’m still concerned if I’m overloading myself with serotonin? My PSSD symptoms are primarily numb genitals and lack of emotion. Any feedback is appreciated.

35-page report on the assessment conducted by the MHRA of antidepressant-related suicidal behaviour/persistent sexual dysfunction and the subsequent risk minimisation measures that are to take effect in 2027.

https://assets.publishing.service.gov.uk/media/6acf6ab62de3184ccf8b80f2/PAR_Antidepressant_EWG_Review.pdf

I’ve attached a screenshot of the proposed new warning against persistent sexual dysfunction, which includes use of the term ”PSSD”. I’m hoping this will lead to much more awareness, raising questions about the state of those who weren’t offered these same chances at informed consent.

It’s still not good enough and doesn’t do much to help current sufferers, besides affirming a small portion of the debilitating symptoms we wake up to and have no choice but to deal with daily. There are also issues with the phrasing that greatly frustrate me.

But it’s a start, and will hopefully encourage more patients to speak out.

I was about to take my first dose of escitalopram (10 mg) prescribed by my psychiatrist. I literally have the pill sitting on the table in front of me, but after reading about the potential side effects especially PSSD, I'm starting to think my social anxiety isn't severe enough to justify the risks lol

thank you all I'll do my best to spread awareness about this. I really wish psychiatrists were more upfront about these risks, cause mine said it's totally safe one of the safest SSRI

You can read about my PSSD-situation here:

M32: Helpless case, in hell for > 10 years after Citalopram : r/PSSD

I meanwhile sent > 1.000 e-mails to psychiatric, neurologic, urologic, andrologic and pharmacologic societies worldwide and to people who work in this field to ask for any kind of help. I got a reply from a sexual therapist from Munich who suggested Lisdexamfetamine. His source is: Stephen M. Stahl: Prescriber´s Guide. You can download the first version of this book here: Prescriber's Guide - Children and Adolescents: Volume 1: Stahl's Essential Psychopharmacology [1 ed.] 9781108446563, 9781108561402, 1108446566 - DOKUMEN.PUB

In the book, the three substances Lisdexamfetamine / Amphetamine-D / Amphetamine-D,L are claimed about: "Can reverse sexual dysfunction caused by psychiatric illness and by some drugs such as SSRIs, including decreased libido, erectile dysfunction, delayed ejaculation, and anorgasmia".

Has anyone of you tried one of these substances?

Just to clarify, I’m non-PSSD, got my syndrome from ketoconazole and Covid, share all the symptoms with PSSD/PFS/PAS and others.

I noticed that some of us, regardless of their syndrome, have lost not only erogenous sensation of their genitals, but also tactile and temperature sensation. I, for example, barely feel touch, pain, hot and cold temperatures in my penis.

Most of you only lost temperature sensation in their glans for some reason, but an acquaintance of mine with PSSD whose numbness is similar to mine just told me that there are plenty of cases that lost all sensation in the entire genital region. So, how common do you think that is?

​

I want to hear from as many men as possible who are experiencing these issues.

Do you have absent morning erections but normal erections during the day?

Do you have both absent morning erections and erectile dysfunction (ED)?

Do you have ED but still get morning erections?

Please share your experience and, if you're comfortable, your age and how long you've been experiencing these symptoms.

I'm looking for as many responses as possible because I've already lost many years trying to understand my own situation. Your answers could really help me understand whether other men experience the same thing.

Please take a moment to respond, even if it's just one line. I'd genuinely appreciate it.

PSSD does not do the actual syndrome we are living with justice. I WISH it was just SD. I often wonder if people would understand us if we were named something like PSD (Post-SSRI Syndrome) or even PSNS (Post-SSRI Neurological Syndrome). What do you guys think?

When you saw and symptoms of cognitive and skin

This mostly NON-sexual.

Does anyone else feel like they cannot visualize things in their mind anymore?

Is this the same as "Aphantasia"?

wondering if you tried did it help or harm you? I’m planning to do a 3 day wet fast I am healthy enough to do it but want to make sure people have done it before and doesn’t carry psd related risks

What are symptoms of pssd?

Is there treatment available to reverse pssd?

​

I have a few questions for people who have undergone a penile Doppler ultrasound:

What happens during the test? Could you explain the procedure step by step?

Who usually performs it—a urologist, a radiologist, or another specialist?

Is it safe? Are there any side effects or risks?

Does the test involve an injection into the penis? If yes, is it painful?

Why were you recommended this test? Was it for erectile dysfunction, lack of morning erections, or another reason?

How long does the test take, and how uncomfortable is it?

Is it possible to undergo the test without an injection?

I'd appreciate it if you could share your personal experiences, especially if you were initially nervous about the procedure.

Thank you!

Hi there,

to those of you who benefit from Viagra, how often (per week) can you take before it loses its effects? I am curious about your experiences

How do you deal with extreme restlessness, agitation, and tic disorders?

I'm so ashamed to be around people that I'd rather just isolate myself all the time.

It's so hard to suppress this restlessness, and I always focus on it

Hello everyone,
Below is the roundup of all the best PSSD related news from last month in one spot.

--------------------------------------------------------------------------------------------------------------

PSSD Network Q3 Research Update

This Q3 2026 update highlights important PSSD research progress, new adverse-event data, efforts to improve PSSD recognition, and ongoing organizational developments.

PSSD In The Media

• Another Blewchew article

PSSD In Social Media

• Elliot Bewick interviews Dr. Joseph Witt-Doerring on his podcast about PSSD
• Lauren Friedman interviewed by psychiatrist and researcher Anders Sorenson
• Another psychiatrist on instagram discusses PSSD
• Historian of psychiatry Andrew Scull explains permanent sexual side effects of SSRIs on the Lex Fridman podcast

Clinical Acknowledgement/Recognition of PSSD

• Psychiatry in Motion, a private psychiatry practice serving multiple US states, has a page which acknowledges PSSD
• Outro health, a telehealth/mental health company focused on tapering, has a page on PSSD
• Refresh Psychiatry & Therapy, a psychiatry and therapy practice in Florida, discusses the subject of PSSD in this article by describing it as a recognized but clinically contested and poorly quantified problem
• The international-patient website for Acıbadem Healthcare Group, a large private hospital network based in Turkey, has a page with a section for PSSD.

More Scientific Milestones

• New study: Polish scientific review article: Persistent Sexual Dysfunction After SSRIs and SNRIs: A Clinical Framework for Assessment, Counseling, and Pharmacovigilance. This review argues that persistent sexual dysfunction after stopping SSRIs/SNRIs is a clinically important but still poorly quantified adverse effect that warrants careful assessment, counseling, and formal pharmacovigilance reporting.
• 2026 narrative review titled “Sexual Dysfunction Associated with Selective Serotonin Reuptake Inhibitors: Mechanisms, Clinical Manifestations, Management Strategies, and Post-SSRI Sexual Dysfunction.” It reviews both ordinary SSRI-associated sexual dysfunction during treatment and persistent symptoms after discontinuation, i.e PSSD.
• Application of Transcranial Magnetic Stimulation in the Treatment of Sexual Dysfunction Associated with Selective Serotonin Reuptake Inhibitor Therapy - a narrative reviewThis publication aims to examine the possible effects of Transcranial Magnetic Stimulation (TMS) on PSSD and propose a non-invasive neuromodulatory approach as a potential avenue for therapeutic exploration, as well as explore pathophysiology and neural correlates of PSSD.

Please tell what help you with this ?
I need to do something

How many here suffer from widespread body numbness alongside localised genital/erogenous numbness? It’s not a symptom I see mentioned as often as others but it really bothers me.

Well, the title speaks for itself.

I would consider my symptoms relatively mild (so far I think I only have a lack of sexual arousal and that is it) and I recently I found this professor that is sort of into neuroscience and sexology and it looks really promising.

But honestly, I do not know what to expect at all. Like, what do I want to get from this? Obviously, all of us want our symptoms gone once and for all and just forget this like it was just a bad dream but I understand this might never happen. I understand that there is no cure and experimenting sometimes makes things even worse. I am not saying experimenting is totally worthless, but I have to know the what and why.

This makes me think: what should I expect in reality?

I totally understand that even this doctor might simply laught it all off and simply attribute it to "depression" and "psychological issues" like all doctors do, despite the fact that I have had a totally normal, almost stress free life in the past 3 years and never felt/been diagnosed with depression.

I also want to point out is that I totally understand it is worth shooting a shot and it is not a question of money at all since I have a pretty good health insurance. But I am also NOT that type of person who would do something only "because it does not hurt". I should know what I am doing it for and not waste my energy and time.

What do you guys think?

Hello,

I'm not too deep into the topic.

Are trycyclic ADs safer or worse when it comes to pssd?

Thanks

Even when I try taking certain vitamins in small doses, my body seems to react strongly. Either my skin becomes even drier or thiner, I experience strange fat loss throughout my body, my hair becomes even thinner, or my mood deteriorates.T here are other things as well that I can't remember right now.

Everything affects me dramatically. What mechanism could be behind this?