context (slight spoilers for mgsv):

-Eshmel's name sounds like Ishmael, and Eshmel's body was constructed- which is kind of like how the msf medic becomes Venom Snake via plastic surgery and induced hypnagogia;

-when Fortuna talks to Eshmel for the first time, she asks if they "have come to" (this obviously calls back to when "V has come to", aka, when Snake awakens);

-Leda's route focuses on her path of revenge- like how Venom Snake and Kazuhira go on a similar path to destroy both XOF and Skull Face;

-Dietrich seeks to fight a giant sea monster, which reminded me of that one whale scene during the opening to mgsv.