r/Nootropics • • 13h ago

Discussion Where do you buy orexin antagonists in the EU?

10 Upvotes

Daridorexant is the only approved med where I live but it's not in stock. Are there online vendors that sell any orexin antagonist? I've looked through plenty of gray area pharmacies as well as nootropic sites and none have orexin antagonists. Is there a site that does?


r/Nootropics • • 23h ago

Discussion Does selank help with anxiety/rejection sensitive dysphoria?

6 Upvotes

Diagnosed ADHD and anxiety. I'm essentially really anxious at baseline and to events. I bring baseline anxiety somewhat down using ashwaghanda but it doesn't help much with acute anxiety spikes and rejection sensitive dysphoria. Propranolol is useless for the mental aspect of it as well. Guanfacine and clonidine aren't available. Stimulants don't make anxiety better or particularly worse.

Is Selank worth a try for this or is it most likely a waste of money? Does anyone have an experience with it for anxiety/RSD?


r/Nootropics • • 23h ago

Experience Seltorexant is completely dogshit

6 Upvotes

This might the most piece of shit sleeping med I have ever tried. 5mg? Nothing. 10mg? Nothing. 20mg? Nothing. If I wasnt such a dumb chud I mightve read the clinical trials to see it barely outperforms placebo

Why the fuck would anyone ever use this shit I have no idea what compelled siradalot to start selling this trash but man is it fucking pointless.

As if DORAS werent already mild enough, what geinune enstein at john and johnson decided it would be a great idea to do away with orx1 antagonism (you know the part thats responsible for 90% of the sedation) and only go for orx2 antagonsim(the one that barely affects arousal). Id imagine its because orx2 is easier to hit so they wanted to cheap out but fuck man what a goyim

Anyways do not waste 30$ on this piece of shit the trials show its placebo any positive anecdote is probably fron 1. A depressive/gad idiot on 10 ssris(you could give these people catpiss and theyd outperform placebo they have so many comorbid disorders), 2. A jeet in the slums of mumbai being paid to spew fake anecdotes on supplement/biohacking forums(happen very often).

A basic mechanistic evaulation would also lead anyone to the conclusion that it is garbage and was developed purely because they couldnt find a cheap structure targetting orx1. This is what happens when you pick products to release off geminis research


r/Nootropics • • 17h ago

Discussion Best nootropicd for sleep?

5 Upvotes

nootropics aren't directly sleep drugs but sleep drugs can be nootropic by treating insomnia.

Are there good meds like that? Something gray market because I've already tried all reasonable pharma options and newer ones like orexin agonists are overpriced.


r/Nootropics • • 5h ago

Discussion What antidepressant nootropics are there?

2 Upvotes

What nootropics/research chemicals act as great antidepressants? Specifically for anxious depression, so preferably something that has anxyoltic properties as well. (Besides racetams and TAK).


r/Nootropics • • 13h ago

Discussion Bromantane from aniracetam or semaxpolska?

0 Upvotes

Asked about bromantane vendorsearlier and chose 2 aniracetam and semaxpolska. Which one is better?